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Invitrogen™ C1q Monoclonal Antibody (3R9/2)
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Catalog No. MA183963
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MA183963 100 μL
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Catalog No. MA183963 Supplier Invitrogen™ Supplier No. MA183963
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Description

Mouse Monoclonal Antibody

A suggested positive control for immunohistochemical applications for this product is kidney tissue from patients with streptococcal glomerulonephritis. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant). Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a approximately 156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system.

C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C1q
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3R9/2
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation BBS with < 0.1% sodium azide; pH 8.4
Gene C1QA
Gene Accession No. P02745, P02746, P02747
Gene Alias AI255395; AI385742; C1q; C1qa; C1qb; C1qc; C1Q-C; C1QG; Ciqc; complement C1q A chain; complement C1q B chain; complement C1q C chain; complement C1q chain A; complement C1q chain B; complement C1q subcomponent subunit A; complement C1q subcomponent subunit A-like protein; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, c polypeptide; complement component 1, q subcomponent, gamma polypeptide; complement component C1q, A chain; complement component C1q, B chain; complement subcomponent C1q chain B
Gene Symbols C1QA, C1QB, C1qc
Host Species Mouse
Immunogen Globular head domain of C1q, purified from human plasma.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 712, 713, 714
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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