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Invitrogen™ C1rLP Polyclonal Antibody
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Catalog No. PIPA545992
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100 μL
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Catalog No. Quantity
PIPA545992 100 μL
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Catalog No. PIPA545992 Supplier Invitrogen™ Supplier No. PA545992
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Description

Rabbit Polyclonal Antibody

Peptide sequence: KVQNHCQEPY YQAAAAGALT CATPGTWKDR QDGEEVLQCM PVCGRPVTPI Sequence homology: Human: 100%; Mouse: 90%.

Complement component 1, r subcomponent-like protein (C1rLP) is part of the complement system, primarily involved in innate immunity. Located on human chromosome 12p13.31, C1rLP is closely related to C1r, a serine protease component of the C1 complex in the classical pathway of complement activation. C1rLP shares structural similarities with C1r, featuring serine protease domains that are crucial for the proteolytic processing required to activate the complement cascade. The precise functional role of C1rLP remains under investigation, but it is hypothesized to act as a modulator of complement activation, potentially influencing immune cell behavior during inflammation or infection. The potential existence of several isoforms of C1rLP suggests diverse regulatory functions, which could impact processes like opsonization, pathogen clearance, and inflammation. Current research explores its relevance in immune response regulation, with implications for understanding autoimmune and inflammatory diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C1rLP
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene C1RL
Gene Accession No. Q9NZP8
Gene Alias C1RL; C1RL1; C1r-like protein; C1r-like serine protease analog protein; C1RLP; C1r-LP; CLSPA; complement C1r subcomponent like; complement C1r subcomponent-like protein; complement C1r-like proteinase; complement component 1, r subcomponent like protein; complement component 1, r subcomponent-like
Gene Symbols C1RL
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human C1RL.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51279
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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