Invitrogen™ C1rLP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA545992

Catalog No. PIPA545992

Description

Peptide sequence: KVQNHCQEPY YQAAAAGALT CATPGTWKDR QDGEEVLQCM PVCGRPVTPI Sequence homology: Human: 100%; Mouse: 90%.

Complement component 1, r subcomponent-like protein (C1rLP) is part of the complement system, primarily involved in innate immunity. Located on human chromosome 12p13.31, C1rLP is closely related to C1r, a serine protease component of the C1 complex in the classical pathway of complement activation. C1rLP shares structural similarities with C1r, featuring serine protease domains that are crucial for the proteolytic processing required to activate the complement cascade. The precise functional role of C1rLP remains under investigation, but it is hypothesized to act as a modulator of complement activation, potentially influencing immune cell behavior during inflammation or infection. The potential existence of several isoforms of C1rLP suggests diverse regulatory functions, which could impact processes like opsonization, pathogen clearance, and inflammation. Current research explores its relevance in immune response regulation, with implications for understanding autoimmune and inflammatory diseases.

Specifications

• Antigen: C1rLP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C1RL
• Gene Alias: C1RL; C1RL1; C1r-like protein; C1r-like serine protease analog protein; C1RLP; C1r-LP; CLSPA; complement C1r subcomponent like; complement C1r subcomponent-like protein; complement C1r-like proteinase; complement component 1, r subcomponent like protein; complement component 1, r subcomponent-like
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51279
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9NZP8
• Gene Symbols: C1RL
• Immunogen: Synthetic peptide directed towards the middle region of human C1RL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG