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Invitrogen™ C1S (Active) Monoclonal Antibody (M241)
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Catalog No. FERMA548987
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100 μg
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Catalog No. Quantity
FERMA548987 100 μg
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Catalog No. FERMA548987 Supplier Invitrogen™ Supplier No. MA548987
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Description

Mouse Monoclonal Antibody

The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.

Activated C1s is a protein complex involved in the complement system, which is a part of the innate immune system. C1s is a serine protease that cleaves C4 and C2 in the classical pathway of complement activation, leading to the formation of C3 convertase. The activation of C1s is initiated by binding of C1q to antigen-antibody complexes or other ligands. The C1s protein is encoded by the C1S gene, which is located on chromosome 12. Dysregulation of the complement system and C1s activation has been implicated in various diseases, including autoimmune disorders, infections, and inflammatory conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C1S (Active)
Applications Flow Cytometry, Functional Assay, Inhibition Assays, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone M241
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene C1S
Gene Accession No. P09871
Gene Alias Active C1S; C1S; C1s1
Gene Symbols C1S
Host Species Mouse
Immunogen Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 716
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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