Invitrogen™ C1S (Active) Monoclonal Antibody (M241)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA548987

Catalog No. FERMA548987

Description

The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.

Activated C1s is a protein complex involved in the complement system, which is a part of the innate immune system. C1s is a serine protease that cleaves C4 and C2 in the classical pathway of complement activation, leading to the formation of C3 convertase. The activation of C1s is initiated by binding of C1q to antigen-antibody complexes or other ligands. The C1s protein is encoded by the C1S gene, which is located on chromosome 12. Dysregulation of the complement system and C1s activation has been implicated in various diseases, including autoimmune disorders, infections, and inflammatory conditions.

Specifications

• Antigen: C1S (Active)
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% BSA and no preservative
• Gene Accession No.: P09871
• Gene Symbols: C1S
• Immunogen: Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Functional Assay, Inhibition Assays, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: M241
• Conjugate: Unconjugated
• Gene: C1S
• Gene Alias: Active C1S; C1S; C1s1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 716
• Content And Storage: 4°C
• Form: Liquid