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Invitrogen™ C2 Monoclonal Antibody (269716)
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Catalog No. PIMA523970
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100 μg
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Catalog No. Quantity
PIMA523970 100 μg
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Catalog No. PIMA523970 Supplier Invitrogen™ Supplier No. MA523970
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Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant human (rh) C1r, rhC1s, rhC3r, rhC5a, rhFactor B, or rhFactor I is observed. In Western blots, this antibody recognizes rhC2 and rhC2B. Reconstitute at 0.5 mg/mL in sterile PBS.

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 269716
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene C2
Gene Accession No. P06681
Gene Alias ARMD14; C2; C3/C5 convertase; classical-complement pathway C3/C5 convertase; CO2; Complement C2; Complement C2a fragment; Complement C2b fragment; complement component 2; complement component 2 (within H-2S); complement component C2; complement factor C2; DADB-122G4.1; I79_016440; MHC complement component C2
Gene Symbols C2
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human Complement Component C2 Ala21-Leu752.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 717
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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