Invitrogen™ C2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547226

Catalog No. PIPA547226

Description

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) C1r, rhC1s, rhC3a, and rhC5a is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Specifications

• Antigen: C2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C2
• Gene Alias: ARMD14; C2; C3/C5 convertase; classical-complement pathway C3/C5 convertase; CO2; Complement C2; Complement C2a fragment; Complement C2b fragment; complement component 2; complement component 2 (within H-2S); complement component C2; complement factor C2; DADB-122G4.1; I79_016440; MHC complement component C2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 717
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P06681
• Gene Symbols: C2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Component C2 Ala21-Leu752.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov