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Invitrogen™ C2 Polyclonal Antibody
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Catalog No. PIPA587697
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100 μL
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PIPA587697 100 μL
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Catalog No. PIPA587697 Supplier Invitrogen™ Supplier No. PA587697
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Description

Rabbit Polyclonal Antibody

Positive Samples: LO2, 293T, U-87MG Immunogen sequence: LDVSKLTDTI CGVGNMSANA SDQERTPWHV TIKPKSQETC RGALISDQWV LTAAHCFRDG NDHSLWRVNV GDPKSQWGKE FLIEKAVISP GFDVFAKKNQ GILEFYGDDI ALLKLAQKVK MSTHARPICL PCTMEANLAL RRPQGSTCRD HENELLNKQS VPAHFVALNG SKLNINLKMG VEWTSCAEVV SQEKTMFPNL TDVREVVTDQ FLCSGTQEDE SPCKGESGGA VFLERRFRFF QVGLVSWGLY NPCLGSADKN SRKRAPRSKV PPPRDFHINL FRMQPWLRQH LGDVLNFLPL.

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.98 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene C2
Gene Accession No. P06681
Gene Alias ARMD14; C2; C3/C5 convertase; classical-complement pathway C3/C5 convertase; CO2; Complement C2; Complement C2a fragment; Complement C2b fragment; complement component 2; complement component 2 (within H-2S); complement component C2; complement factor C2; DADB-122G4.1; I79_016440; MHC complement component C2
Gene Symbols C2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 453-752 of human C2 (NP_0000542).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 717
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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