Invitrogen™ C2 Recombinant Rabbit Monoclonal Antibody (002)

Catalog No.	Quantity
PIMA530107	100 μL

Catalog No. PIMA530107 Supplier Invitrogen™ Supplier No. MA530107

Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human Complement Component 2.

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Specifications

• Antigen: C2
• Applications: ELISA
• Classification: Recombinant Monoclonal
• Clone: 002
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: C2
• Gene Accession No.: P06681
• Gene Alias: ARMD14; C2; C3/C5 convertase; classical-complement pathway C3/C5 convertase; CO2; Complement C2; Complement C2a fragment; Complement C2b fragment; complement component 2; complement component 2 (within H-2S); complement component C2; complement factor C2; DADB-122G4.1; I79_016440; MHC complement component C2
• Gene Symbols: C2
• Host Species: Rabbit
• Immunogen: Recombinant Human C2 protein (Met1-Leu752).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 717
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG