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  5. Tocris Bioscience™ C28

Tocris Bioscience™ C28
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Catalog No. 754610
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75-461-0 10 mg
75-465-0 50 mg
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Catalog No. 75-461-0 Supplier Tocris Bioscience™ Supplier No. 7546/10
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Description

Potent LMTK3 inhibitor

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

Specifications

Chemical Name or Material 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Quantity 10 mg
Target LMTK3
Molecular Formula C18H11F3N4O
Purity 0.98
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