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C4 binding protein Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS15184R

Catalog No. 50-198-3535


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Description

Description

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.
Specifications

Specifications

C4 binding protein
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
C4BPB
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
725
C4BPB
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P20851
C4b-binding protein beta chain; C4BP; C4BPB; C4bp-ps1; complement component 4 binding protein beta; complement component 4 binding protein, beta; complement component 4 binding protein, pseudogene 1
KLH conjugated synthetic peptide derived from human C4 binding protein.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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