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C4 binding protein Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501983535
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100 μL
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50-198-3535 100 μL
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Catalog No. 50-198-3535 Supplier Bioss Supplier No. BS15184R
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Description

Rabbit Polyclonal Antibody

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.

Specifications

Antigen C4 binding protein
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene C4BPB
Gene Accession No. P20851
Gene Alias C4b-binding protein beta chain; C4BP; C4BPB; C4bp-ps1; complement component 4 binding protein beta; complement component 4 binding protein, beta; complement component 4 binding protein, pseudogene 1
Gene Symbols C4BPB
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human C4 binding protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 725
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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