Invitrogen™ C4BPA Monoclonal Antibody (10-07)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA182815

Catalog No. PIMA182815

Description

Mouse anti human C4bp monoclonal antibody, clone 051-198.6.3 (10-07), recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains.

There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.

Specifications

• Antigen: C4BPA
• Classification: Monoclonal
• Concentration: 1.15 mg/mL
• Formulation: BBS with 0.1% sodium azide; pH 8.4
• Gene Accession No.: P04003
• Gene Symbols: C4BPA
• Immunogen: Native human C4 binding protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Flow Cytometry
• Clone: 10-07
• Conjugate: Unconjugated
• Gene: C4BPA
• Gene Alias: AI195242; C4b-binding protein; C4b-binding protein alpha chain; C4bp; C4bpa; complement component 4 binding protein; complement component 4 binding protein alpha; complement component 4 binding protein, alpha; proline-rich protein; PRP; RP11-164O23.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 722
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

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