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Invitrogen™ C4BPA Polyclonal Antibody
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Catalog No. PIPA596746
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100 μL
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PIPA596746 100 μL
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Catalog No. PIPA596746 Supplier Invitrogen™ Supplier No. PA596746
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QYVEPENVTI QCDSGYGVVG PQSITCSGNR TWYPEVPKCE WETPEGCEQV LTGKRLMQCL PNPEDVKMAL EVYKLSLEIE QLELQRDSAR QSTLDKEL; Positive Samples: A-549, HepG2, HL-60.

There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C4BPA
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.56 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene C4BPA
Gene Accession No. P04003, P08607, Q63514
Gene Alias AI195242; C4b-binding protein; C4b-binding protein alpha chain; C4bp; C4bpa; complement component 4 binding protein; complement component 4 binding protein alpha; complement component 4 binding protein, alpha; proline-rich protein; PRP; RP11-164O23.4
Gene Symbols C4BPA
Host Species Rabbit
Immunogen Synthetic peptide
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12269, 24235, 722
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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