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Invitrogen™ C4BPB Polyclonal Antibody
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Catalog No. PIPA5109469
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100 μL
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PIPA5109469 100 μL
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Catalog No. PIPA5109469 Supplier Invitrogen™ Supplier No. PA5109469
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ASDEHCPELP PVDNSIFVAK EVEGQILGTY VCIKGYHLVG KKTLFCNASK EWDNTTTECR LGHCPDPVLV NGEFSSSGPV NVSDKITFMC NDHYILKGSN RSQCLEDHTW APPFPICKSR DCDPPGNPVH GYFEGNNFTL GSTISYYCED RYYLVGVQEQ QCVDGEWSSA LPVCKLIQEA PKPECEKALL AFQESKNLCE AMENFMQQLK ESGMTMEELK YSLELKKAEL KAKLL.

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C4BPB
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.78 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene C4BPB
Gene Accession No. P20851, Q63515
Gene Alias C4b-binding protein beta chain; C4BP; C4BPB; C4bp-ps1; complement component 4 binding protein beta; complement component 4 binding protein, beta; complement component 4 binding protein, pseudogene 1
Gene Symbols C4bp-ps1, C4BPB
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 17-251 of human C4BPB (NP_0010173641).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12270, 24236, 725
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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