Invitrogen™ C5AR1 Chimeric Recombinant Rabbit Monoclonal Antibody (S5/1)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA548288

Catalog No. PIMA548288

Description

Specificity: S5/1 antibody recognizes the C5aR (CD88) protein, a 43 kDa receptor of C5a component of the complement cascade.

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

Specifications

• Antigen: C5AR1 Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P21730, Q9TUE1
• Gene Symbols: C5AR1
• Immunogen: This antibody was raised by immunizing mice with a synthetic peptide corresponding to C5a-R; amino acids: 1-31 (N terminal).
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Rabbit, Bovine, Ferret
• Product Type: Antibody
• Isotype: IgG κ

• Applications: ELISA, Flow Cytometry, Functional Assay, Inhibition Assays, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: S5/1
• Conjugate: Unconjugated
• Gene: C5AR1
• Gene Alias: anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100352978, 101692871, 493645, 728
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid