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Invitrogen™ C5AR1 Monoclonal Antibody (8D6)
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Catalog No. PIMA170060
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250 μg
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PIMA170060 250 μg
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Catalog No. PIMA170060 Supplier Invitrogen™ Supplier No. MA170060
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Description

Rat Monoclonal Antibody

MA1-70060 detects C5a receptor in human samples. MA1-70060 has been successfully used in flow cytometry and immunohistochemistry (frozen sections) procedures. The MA1-70060 immunogen is RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C5AR1
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone 8D6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene C5AR1
Gene Accession No. P21730
Gene Alias anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1
Gene Symbols C5AR1
Host Species Rat
Immunogen RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 728
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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