Invitrogen™ cGAS Monoclonal Antibody (1697CT136.65.30)

Catalog No.	Quantity
PIMA537714	200 μL

Catalog No. PIMA537714 Supplier Invitrogen™ Supplier No. MA537714

Description

Mouse Monoclonal Antibody

cGAS Monoclonal Antibody for Western Blot

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.

Specifications

• Antigen: cGAS
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 1697CT136.65.30
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: CGAS
• Gene Accession No.: Q8N884
• Gene Alias: C6orf150; h-cGAS; MB21D1
• Gene Symbols: CGAS
• Host Species: Mouse
• Immunogen: KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.
• Purification Method: Protein G
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 115004
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ