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Invitrogen™ C7orf60 Polyclonal Antibody
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Catalog No. PIPA565637
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100 μL
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PIPA565637 100 μL
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Catalog No. PIPA565637 Supplier Invitrogen™ Supplier No. PA565637
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QERKLEQEKLS GVVKSVHRRL RKKYREVGDF DKIWREHCED EETLCEYAVA MKNLADNHWA KTCEGEGRIE WCCSVCREYF Q Highest antigen sequence identity to the following orthologs - mouse 99%, rat 38%.

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen C7orf60
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BMT2
Gene Accession No. Q1RMZ1
Gene Alias base methyltransferase of 25S rRNA 2 homolog; BMT2; C7orf60; Probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog; S-adenosylmethionine sensor upstream of mTORC1; SAMTOR; UPF0532 protein C7orf60
Gene Symbols BMT2
Host Species Rabbit
Immunogen Recombinant Human C7orf60. Recombinant protein control fragment (Product #RP-106306).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 154743
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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