Invitrogen™ C8orf48 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555222

Catalog No. PIPA555222

Description

Immunogen sequence: KWINYLKLKD SNFERHQPDT KLPTEITRVS DEELNALQSY CTMKINLIHR RGDSKKKTSS RHKKLHLGLD V Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 26%.

The C8orf48 gene has been identified as a critical biomarker in colorectal cancer (CRC). Research indicates that C8orf48 plays a significant role in inhibiting tumorigenesis by regulating key signaling pathways. This gene is negatively associated with KRAS, BRAF, and MAP2K2 in normal colorectal tissues and negatively correlated with MAP2K2 in CRC tissues. These associations suggest that C8orf48 may function as a tumor suppressor by modulating pathways involved in cell proliferation, migration, and invasion. The gene's expression and methylation profiles have been extensively studied using data from The Cancer Genome Atlas (TCGA), and functional assays have confirmed its inhibitory effects on CRC cell growth. Additionally, C8orf48 has been identified as a direct target of miR-556, further elucidating its regulatory mechanisms. The findings underscore the potential of C8orf48 as a novel target for CRC prediction and therapy.

Specifications

• Antigen: C8orf48
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C8orf48
• Gene Alias: C8orf48; chromosome 8 open reading frame 48; uncharacterized protein C8orf48
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 157773
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96LL4
• Gene Symbols: C8orf48
• Immunogen: Recombinant protein corresponding to Human C8orf48. Recombinant protein control fragment (Product #RP-93866).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG