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Invitrogen™ C8orf48 Polyclonal Antibody
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Catalog No. PIPA555222
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100 μL
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PIPA555222 100 μL
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Catalog No. PIPA555222 Supplier Invitrogen™ Supplier No. PA555222
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KWINYLKLKD SNFERHQPDT KLPTEITRVS DEELNALQSY CTMKINLIHR RGDSKKKTSS RHKKLHLGLD V Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 26%.

The C8orf48 gene has been identified as a critical biomarker in colorectal cancer (CRC). Research indicates that C8orf48 plays a significant role in inhibiting tumorigenesis by regulating key signaling pathways. This gene is negatively associated with KRAS, BRAF, and MAP2K2 in normal colorectal tissues and negatively correlated with MAP2K2 in CRC tissues. These associations suggest that C8orf48 may function as a tumor suppressor by modulating pathways involved in cell proliferation, migration, and invasion. The gene's expression and methylation profiles have been extensively studied using data from The Cancer Genome Atlas (TCGA), and functional assays have confirmed its inhibitory effects on CRC cell growth. Additionally, C8orf48 has been identified as a direct target of miR-556, further elucidating its regulatory mechanisms. The findings underscore the potential of C8orf48 as a novel target for CRC prediction and therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C8orf48
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene C8orf48
Gene Accession No. Q96LL4
Gene Alias C8orf48; chromosome 8 open reading frame 48; uncharacterized protein C8orf48
Gene Symbols C8orf48
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human C8orf48. Recombinant protein control fragment (Product #RP-93866).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 157773
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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