C9a/C9 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1156	100 μL

Catalog No. 50-198-1156 Supplier Bioss Supplier No. BS11190R

Description

Rabbit Polyclonal Antibody

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.

Specifications

• Antigen: C9a/C9
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: C9
• Gene Accession No.: P02748
• Gene Alias: ARMD15; C9; C9D; complement component 9; Complement component C9; Complement component C9a; Complement component C9b; complement protein C9; LOC100037951
• Gene Symbols: C9
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Complement component C9a.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 735
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG