C9orf72 Polyclonal Antibody, Rockland™

Chicken Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-1300	Rockland Immunochemicals 200901MH2	100 μg
50-199-1301	Rockland Immunochemicals 200901MH2S	25 μL

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human C9orf72. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and rat.

C9orf72 may play a role in endosomal trafficking and autophagy. It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases. C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome. Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.

Specifications

• Antigen: C9orf72
• Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry
• Conjugate: Unconjugated
• Host Species: Chicken
• Target Species: Human
• Gene Accession No.: Q96LT7
• Gene ID (Entrez): 203228
• Immunogen: Anti-C9orf72 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human C9orf72 surrounding aa 425-481 conjugated to Keyhole Limpet Hemocyanin (KLH).
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: C9orf72

• Concentration: 1.03 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 0.002M sodium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7
• Gene Alias: 3110043O21Rik; AI840585; ALSFTD; C9orf72; chromosome 9 open reading frame 72; FTDALS; FTDALS1; Guanine nucleotide exchange C9orf72; Guanine nucleotide exchange C9orf72 homolog; protein C9orf72; protein C9orf72 homolog; RIKEN cDNA 3110043O21 gene
• Gene Symbols: C9orf72
• Primary or Secondary: Primary
• Product Type: Antibody