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CA9 Mouse anti-Human, Clone: OTI1G7, liquid, TrueMAB™
SDP

Catalog No. 501671765
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50-167-1765 100 μL
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Catalog No. 50-167-1765 Supplier OriGene Supplier No. TA500623
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Description

Mouse Monoclonal Antibody

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Specifications

Antigen CA9
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1G7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CA9
Gene Accession No. Q16790
Gene Alias CAIX, MN
Gene Symbols CA9
Host Species Mouse
Immunogen Full-length protein expressed in 293T cell transfected with human CA9 expression vector
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 768
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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