Invitrogen™ CAB39 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529172

Catalog No. PIPA529172

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Mouse (99%), Zebrafish (92%), Xenopus laevis (98%), Rhesus Monkey (99%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).

Specifications

• Antigen: CAB39
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAB39
• Gene Alias: AA408805; AA960512; C78372; Cab39; calcium binding protein 39; calcium binding protein, 39 kDa; calcium-binding protein 39; CGI-66; MO25; MO25alpha; Protein Mo25
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12283, 51719
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.97 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q06138, Q9Y376
• Gene Symbols: CAB39
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 341 of Human CAB39.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov