Invitrogen™ CaBP8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100419

Catalog No. PIPA5100419

Description

Antibody detects endogenous levels of total CALN1.

Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.

Specifications

• Antigen: CaBP8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CALN1
• Gene Alias: 9630012C17Rik; CABP8; calcium-binding protein 8; calcium-binding protein CABP8; CALN1; calneuron 1; calneuron I; Calneuron-1; calneuron-I; MNCb-0849
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140904, 363909, 83698
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q06BI3, Q9BXU9, Q9JJG7
• Gene Symbols: CALN1
• Immunogen: A synthesized peptide derived from human CALN1(Accession Q9BXU9), corresponding to amino acid residues M86-L136.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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