Invitrogen™ CACNG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106768

Catalog No. PIPA5106768

Description

Antibody detects endogenous levels of total CACNG1.

Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.

Specifications

• Antigen: CACNG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cacng1
• Gene Alias: Cacng; Cacng1; CACNLG; calcium channel, voltage-dependent, gamma subunit 1; calcium voltage-gated channel auxiliary subunit gamma 1; dihydropyridine receptor gamma 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; L-type calcium channel gamma polypeptide; neuronal dihydropyridine-sensitive calcium channel gamma subunit; voltage-dependent calcium channel gamma-1 subunit
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12299, 29658, 786
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O70578, P97707, Q06432
• Gene Symbols: Cacng1
• Immunogen: A synthesized peptide derived from human CACNG1(Accession Q06432), corresponding to amino acid residues L136-C186.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov