Invitrogen™ CACTIN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560019

Catalog No. PIPA560019

Description

Immunogen sequence: SLDDYDAGRY SPRLLTAHEL PLDAHVLEPD EDLQRLQLSR QQLQVTGDAS ESAEDIFFRR AKEGMGQDEA QFSVEMPLTG Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.

Specifications

• Antigen: CACTIN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CACTIN
• Gene Alias: 2510012J08Rik; C19orf29; C20H19orf29; CACTIN; cactin, spliceosome C complex subunit; fSAPc; functional spliceosome-associated protein c; NY REN 24 antigen; NY-REN-24; NY-REN-24 antigen; renal carcinoma antigen NY-REN-24; RGD1563634
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58509
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WUQ7
• Gene Symbols: CACTIN
• Immunogen: Recombinant protein corresponding to Human CACTIN. Recombinant protein control fragment (Product #RP-98977).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov