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Invitrogen™ CADM1 Polyclonal Antibody
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Catalog No. PIPA5106549
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100 μL
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PIPA5106549 100 μL
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Catalog No. PIPA5106549 Supplier Invitrogen™ Supplier No. PA5106549
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CADM1.

Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CADM1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CADM1
Gene Accession No. Q8R5M8, Q9BY67
Gene Alias 2900073G06Rik; 3100001I08Rik; AI987920; Bl2; cadm1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; Igsf4; Igsf4a; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; immunosuperfamily protein Bl2; Necl2; NECL-2; nectin-like 2; nectin-like protein 2; RA175; RA175A; RA175B; RA175C; RA175N; secretory isoform of TSLC1; sgigsf; Spermatogenic immunoglobulin superfamily; ST17; sTSLC-1; Synaptic cell adhesion molecule; SynCAM; SynCam1; truncated CADM1 protein; TSLC1; TSLC-1; TSLC1/Nectin-like 2/IGSF4; tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog
Gene Symbols CADM1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CADM1(Accession Q9BY67), corresponding to amino acid residues S105-T155.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23705, 54725
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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