CADM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 143351AP150UL

Catalog No. 50-172-9373

Description

Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Specifications

• Antigen: CADM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CADM1
• Gene Alias: BL2, CADM1, cell adhesion molecule 1, IGSF4, IGSF4A, Necl 2, NECL2, Nectin like protein 2, RA175, sgIGSF, ST17, sTSLC 1, SYNCAM, synCAM1, TSLC 1, TSLC1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23705, 363058, 54725
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6AYP5, Q8R5M8, Q9BY67
• Gene Symbols: Cadm1
• Immunogen: CADM1 Fusion Protein Ag5621
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG