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CADM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501729373 Shop All Proteintech Group Inc Products
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50-172-9373 150 μL
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Catalog No. 50-172-9373 Supplier Proteintech Group Inc Supplier No. 143351AP150UL
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Description

Rabbit Polyclonal Antibody

Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Specifications

Antigen CADM1
Applications Western Blot
Classification Polyclonal
Concentration 0.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CADM1
Gene Accession No. Q6AYP5, Q8R5M8, Q9BY67
Gene Alias BL2, CADM1, cell adhesion molecule 1, IGSF4, IGSF4A, Necl 2, NECL2, Nectin like protein 2, RA175, sgIGSF, ST17, sTSLC 1, SYNCAM, synCAM1, TSLC 1, TSLC1
Gene Symbols Cadm1
Host Species Rabbit
Immunogen CADM1 Fusion Protein Ag5621
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23705, 363058, 54725
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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