Invitrogen™ CADM3 Polyclonal Antibody

Catalog No.	Quantity
PIPA547524	100 μg

Catalog No. PIPA547524 Supplier Invitrogen™ Supplier No. PA547524

Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) IGSF4C is observed and less than 2% cross-reactivity with rhIGSF4, rhIGSF4D, and rhIGSF8 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cell adhesion molecule 3 (CADM3), also known as Necl-1, is a gene located on chromosome 1p36.22, encoding a protein that is part of the immunoglobulin superfamily involved in cell-cell adhesion processes. CADM3 is predominantly expressed in the nervous system, particularly in regions such as the brain and spinal cord, where it plays crucial roles in neuronal communication, synapse formation, and maintenance of neural network architecture. The protein functions by mediating homophilic and heterophilic interactions with other cell adhesion molecules, facilitating synapse stabilization and neuronal differentiation. CADM3's activity is essential for proper neural development and function, and dysregulation of its expression has been linked to various neurological disorders. Beyond its role in the nervous system, CADM3 also contributes to tumor suppression in certain cancers, as its expression is often downregulated in tumor tissues. Research into CADM3 continues to explore its potential as a therapeutic target in both neurobiology and oncology.

Specifications

• Antigen: CADM3
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Cadm3
• Gene Accession No.: Q8N126
• Gene Alias: BIgR; brain immunoglobulin receptor; CADM3; Cell adhesion molecule 3; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; NECL1; NECL-1; nectin-like 1; nectin-like protein 1; nectin-lke 1; synaptic cell adhesion molecule 3; SYNCAM3; TSLC1-like 1; TSLC1-like protein 1; TSLL1; UNQ225/PRO258
• Gene Symbols: Cadm3
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human IGSF4B/SynCAM3 isoform 1 Pro21-Tyr329.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 57863
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov