Invitrogen™ CADM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582047

Catalog No. PIPA582047

Description

Immunogen sequence: QLVTSTPHEL SISISNVALA DEGEYTCSIF TMPVRTAKSL VTVLGIPQKP IITGYKSSLR EKDTATLNCQ SSGSKPAARL TWRKGDQELH GEPTRIQEDP NGKTFTVSSS VTFQVTREDD GASIVCSVNH ESLKGADRST SQ.

Cell adhesion molecule 3 (CADM3), also known as Necl-1, is a gene located on chromosome 1p36.22, encoding a protein that is part of the immunoglobulin superfamily involved in cell-cell adhesion processes. CADM3 is predominantly expressed in the nervous system, particularly in regions such as the brain and spinal cord, where it plays crucial roles in neuronal communication, synapse formation, and maintenance of neural network architecture. The protein functions by mediating homophilic and heterophilic interactions with other cell adhesion molecules, facilitating synapse stabilization and neuronal differentiation. CADM3's activity is essential for proper neural development and function, and dysregulation of its expression has been linked to various neurological disorders. Beyond its role in the nervous system, CADM3 also contributes to tumor suppression in certain cancers, as its expression is often downregulated in tumor tissues. Research into CADM3 continues to explore its potential as a therapeutic target in both neurobiology and oncology.

Specifications

• Antigen: CADM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cadm3
• Gene Alias: BIgR; brain immunoglobulin receptor; CADM3; Cell adhesion molecule 3; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; NECL1; NECL-1; nectin-like 1; nectin-like protein 1; nectin-lke 1; synaptic cell adhesion molecule 3; SYNCAM3; TSLC1-like 1; TSLC1-like protein 1; TSLL1; UNQ225/PRO258
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57863
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N126
• Gene Symbols: Cadm3
• Immunogen: Recombinant protein corresponding to Human CADM3. Recombinant protein control fragment (Product #RP-94790).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG