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  5. R&D Systems™ CAF 382

R&D Systems™ CAF 382
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Catalog No. 810550 Shop All Novus Products
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81-055-0 50 mg
81-051-0 10 mg
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Catalog No. 81-055-0 Supplier R&D Systems™ Supplier No. 8105/50

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Description

A Tocris product, part of R&D Systems. Potent and selective CDKL5 inhibitor

CAF 382 is potent and selective CDKL5 (cyclin-dependent kinase-like 5) inhibitor (IC50 = 10 nM). Exhibits nearly 100-fold selectivity for CDKL5 over CDKL2, low inhibition for CDKL3 and CDKL4 (IC50 = 2.1-2.7 ?M), and no inhibition for CDKL1. CAF 382 lacks GSK3β activity. It causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels in rat primary cortical neuron cultures. CAF 382 is an analog of SNS 032 (Cat. No. 4075).

Specifications

Chemical Name or Material N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate
Quantity 50 mg
Product Line Tocris
Target CDKL5
Molecular Formula C16H22N4O2S2.CF3CO2H
Purity 0.98
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