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Invitrogen™ CAF1 p150 Recombinant Rabbit Monoclonal Antibody (1T1O5)
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Catalog No. PIMA538180
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PIMA538180 100 μL
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Catalog No. PIMA538180 Supplier Invitrogen™ Supplier No. MA538180
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, Jurkat, SH-SY5Y Immunogen sequence: NFLRNRIETS IGQSTVIIDL TEDSNEQPDS LVDHNKLNSE ASPSREAING QREDTGDQQG LLKAIQNDKL AFPGETLSDI PCKTEEEGVG CGGAGRRGDS Q.

CAF1 p150 is part of the chromatin assembly factor 1 (CAF-1) complex, a key player in DNA repair and replication processes. CAF-1, composed of p150 (CHAF1A), p60 (CHAF1B), and p48 subunits, functions primarily in the deposition of newly synthesized histones H3 and H4 onto nascent DNA strands, ensuring chromatin is properly assembled during DNA replication and after repair. The p150 subunit is the largest of the CAF-1 complex and is critical for binding DNA and recruiting CAF-1 to replication sites, facilitating histone deposition in a process vital for maintaining genome stability and epigenetic inheritance. Beyond just chromatin formation, CAF1 p150 is involved in influencing gene silencing and the maintenance of heterochromatin, impacting gene regulation notably during development and in response to DNA damage. Its role has implications in oncogenesis, where dysregulation of CAF1 p150 can lead to altered chromatin structures and contribute to tumorigenesis, marking it as an important target in cancer research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CAF1 p150
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 1T1O5
Concentration 0.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CHAF1A
Gene Accession No. Q13111
Gene Alias AL023013; AL024058; Cac1p; CAF; CAF1; CAF-1; CAF-1 subunit A; CAF1B; CAF1P150; CAF-I 150 kDa subunit; CAF-I p150; CAF-Ip150; Caip150; CHAF1A; Chromatin assembly factor 1 subunit A; chromatin assembly factor 1, subunit A (p150); chromatin assembly factor I (150 kDa); chromatin assembly factor I p150 subunit; CTB-50L17.7; hp150; MGC71229; P150
Gene Symbols CHAF1A
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p150 CAF1 (NP_0054742).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10036
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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