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MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides

A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.

$279.00

Specifications

Color Light Brown
Description 95% by HPLC
Target Proteins PKC
CAS 121263-19-2
Molecular Formula C44H38O14
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
20-872-5100UG
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MilliporeSigma™
208725100UG
100 μg
Each for $279.00
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20-872-550UG
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MilliporeSigma™
20872550UG
50 μg Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area. N/A
Description

Description

A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5μM), protein kinase A (IC50 > 50μM), protein kinase G (IC50 > 25μM), and p60v- src (IC50 > 50μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
Specifications

Specifications

Light Brown
PKC
C44H38O14
DMSO or EtOH
Lyophilized
95% by HPLC
121263-19-2
790.8g/mol
Protect from light
SDS
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Documents

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