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  6. 20389110MG

MilliporeSigma™ Calbiochem™ CRAC Channel Inhibitor III, Pyr6

Catalog No. 20389110MG
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Quantity:
10 mg

Description

A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon

A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol (Cat. No. 212385) stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46μM; by Fura-2). A great complement to Pyr2 (Cat. No.203890), Pyr3 (Cat. No. 648490), and Pyr10 (Cat. No. 648494) in Ca2+ signaling studies.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Beige
Description 99% by HPLC
Target Proteins Orai3
Molecular Formula C17H9F7N4O
Formula Weight 418.3g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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