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EMD Millipore Calbiochem™ Cyclopamine, V. californicum

Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.

Manufacturer:  EMD Millipore 2398031MG

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Catalog No. 23-980-31MG

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A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10mm solution in Ethanol (Cat. No. 239806).
Description & Specifications


97% by HPLC
Protect from Light
Hh signaling in Shh-light2 assay
Off-white solid
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