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MilliporeSigma™ Calbiochem™ MIF Antagonist III, 4-IPP

A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat

Manufacturer:  MilliporeSigma™ 47584610MG

Catalog No. 47-584-610MG


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Description

Description

A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC50 ~5 vs. 50µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10µM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10µM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50µM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1mg/animal/day or ~50mg/kg/day via i.p.) in vivo .
Specifications

Specifications

90% by HPLC
Protect from Light
41270-96-6
282.1g/mol
Amber solid
10mg
C10H7IN2
DMSO
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