MilliporeSigma™ Calbiochem™ MIF Antagonist III, 4-IPP

Description

A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat

A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC₅₀ ∽5 vs. 50μM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10μM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10μM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50μM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1mg/animal/day or ∽50mg/kg/day via i.p.) in vivo .

Specifications

• Color: Amber
• Description: 90% by HPLC
• CAS: 41270-96-6
• Molecular Formula: C₁₀H₇IN₂
• Formula Weight: 282.1g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg