MilliporeSigma™ Calbiochem™ MitoBloCK-6

Catalog No.	Quantity
50-575-90001	25 mg

Catalog No. 50-575-90001 Supplier MilliporeSigma™ Supplier No. 5057590001

Description

A cell-permeable, stable dichlorosalicylaldehyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC₅₀ = 700 nM, 900 nM, an

A cell-permeable, stable dichlorosalicylaldehyde Schiff′s base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC₅₀ = 700 nM, 900 nM, and 1.4μM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (∽100μM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (∽20μM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochondrial dysfunction.

Specifications

• Color: Orange
• Description: 98% by HPLC
• Target Proteins: Erv1
• Molecular Formula: C₁₉H₁₄Cl₂N₂O
• Formula Weight: 357.2g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 25 mg