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EMD Millipore Calbiochem™ Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride

Inhibits trypsin-like serine proteinases.

Manufacturer:  EMD Millipore 616382250MG

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Catalog No. 61-638-2250MG

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Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
Description & Specifications


95% by elemental analysis
trypsin like proteases
Aqueous solutions (unstable above pH 6.0)
Off-white solid
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