MilliporeSigma™ Calbiochem™ PKR Inhibitor III, 7DG CAS 26927-01-5

Description

A cell-permeable gedunin analog

A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IκK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IκBβ degradaion (20μM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10μM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16 (Cat. Nos. 527450 and 527451), but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment.

Specifications

• Color: Pale Yellow
• Description: 95% by HPLC
• Target Proteins: PKR
• Molecular Formula: C₂₆H₃₀O₅
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 5 mg