Invitrogen™ Calcineurin A Polyclonal Antibody

Catalog No.	Quantity
PIPA529255	100 μL

Catalog No. PIPA529255 Supplier Invitrogen™ Supplier No. PA529255

Description

Rabbit Polyclonal Antibody

Recommended positive controls: human PPP3CA-transfected 293T, mouse brain, Rat brain. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (93%), Xenopus laevis (98%), Dog (100%), Pig (99%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Specifications

• Antigen: Calcineurin A
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.77 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: PPP3CA
• Gene Accession No.: P63328, P63329, Q08209
• Gene Alias: 2900074D19Rik; Ca2+/calmodulin-regulated protein phosphatase; calcineurin; calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; calcineurin catalytic subunit delta isoform; Calcineurin subunit A alpha; CalcineurinA; calmodulin-dependent calcineurin A subunit alpha isoform; caln; CALNA; CALNA 1; CALNA1; CAM-PRP catalytic subunit; CCN 1; ccn1; CN; CnA; CNA alpha; CNA1; PP2B alpha 1; PP2BA alpha; PP2CB; ppp2b; ppp3ca; ppp3ca.S; protein phosphatase; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isozyme S homeolog; protein phosphatase 3, catalytic subunit, gamma isozyme; protein phosphatase-2Ba; serine/threonine protein kinase; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; XELAEV_18009418mg
• Gene Symbols: PPP3CA
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Calcineurin A. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19055, 24674, 5530
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov