Invitrogen™ Calcineurin A Recombinant Rabbit Monoclonal Antibody (JA64-11)

Catalog No.	Quantity
PIMA532650	100 μL

Catalog No. PIMA532650 Supplier Invitrogen™ Supplier No. MA532650

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Specifications

• Antigen: Calcineurin A
• Applications: Flow Cytometry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JA64-11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: PPP3CA
• Gene Accession No.: P63328, P63329, Q08209
• Gene Alias: 2900074D19Rik; Ca2+/calmodulin-regulated protein phosphatase; calcineurin; calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; calcineurin catalytic subunit delta isoform; Calcineurin subunit A alpha; CalcineurinA; calmodulin-dependent calcineurin A subunit alpha isoform; caln; CALNA; CALNA 1; CALNA1; CAM-PRP catalytic subunit; CCN 1; ccn1; CN; CnA; CNA alpha; CNA1; PP2B alpha 1; PP2BA alpha; PP2CB; ppp2b; ppp3ca; ppp3ca.S; protein phosphatase; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isozyme S homeolog; protein phosphatase 3, catalytic subunit, gamma isozyme; protein phosphatase-2Ba; serine/threonine protein kinase; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; XELAEV_18009418mg
• Gene Symbols: PPP3CA
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human Calcineurin A aa 472-521.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19055, 24674, 5530
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG