Invitrogen™ Calcitonin Receptor Monoclonal Antibody (31/01-1H10-4-1-14)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528094

Catalog No. PIMA528094

Description

Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes the human calcitonin receptor, a membrane protein with seven transmembrane domains that is coupled to G protein messenger systems.

The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.

Specifications

• Antigen: Calcitonin Receptor
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with <0.1% sodium azide
• Gene Accession No.: P30988
• Gene Symbols: CALCR
• Immunogen: Synthetic peptide, DIPIYICHQELRNEPANN, derived from the cytoplasmic domain of human calcitonin receptor.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 31/01-1H10-4-1-14
• Conjugate: Unconjugated
• Gene: CALCR
• Gene Alias: C1A/C1B; calcitonin receptor; CALCR; Clr; COPT1; CRT; CT receptor; CTR; CT-R; CTR1; hCTR1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid