Invitrogen™ CALHM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553779

Catalog No. PIPA553779

Description

Immunogen sequence: CTEHAKAFAK VCIQQFFEAM NHDLELGHTH GTLATAPASA AAPTTPDGAE EEREKLRGIT DQGTMNRLLT SWHKCKPPLR LGQEEPPLMG NGW Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 80%.

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Specifications

• Antigen: CALHM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Calhm1
• Gene Alias: calcium homeostasis modulator 1; calcium homeostasis modulator protein 1; Calhm1; EG546729; Fam26c; family with sequence similarity 26, member C; Protein FAM26C; RGD1564891
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 255022
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IU99
• Gene Symbols: Calhm1
• Immunogen: Recombinant protein corresponding to Human CALHM1. Recombinant protein control fragment (Product #RP-91132).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG