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Invitrogen™ CALHM1 Polyclonal Antibody
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Catalog No. PIPA5109478
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100 μL
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PIPA5109478 100 μL
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Catalog No. PIPA5109478 Supplier Invitrogen™ Supplier No. PA5109478
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VRSVRPCFTQ AAFLKSKYWS HYIDIERKLF DETCTEHAKA FAKVCIQQFF EAMNHDLELG HTHGTLATAP ASAAAPTTPD GAEEEREKLR GITDQGTMNR LLTSWHKCKP PLRLGQEEPP LMGNGWAGGG PRPPRKEVAT YFSKV.

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CALHM1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.46 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Calhm1
Gene Accession No. Q8IU99
Gene Alias calcium homeostasis modulator 1; calcium homeostasis modulator protein 1; Calhm1; EG546729; Fam26c; family with sequence similarity 26, member C; Protein FAM26C; RGD1564891
Gene Symbols Calhm1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 255022, 499367
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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