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Invitrogen™ CALM Polyclonal Antibody
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Catalog No. PIPA5115756
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100 μL
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PIPA5115756 100 μL
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Catalog No. PIPA5115756 Supplier Invitrogen™ Supplier No. PA5115756
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PICALM.

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CALM
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene Picalm
Gene Accession No. O55012, Q13492, Q7M6Y3
Gene Alias CALM; Clathrin assembly lymphoid myeloid leukemia; clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; CLTH; fit1; fit-1; LAP; mKIAA4114; PAP180; phosphatidylinositol binding clathrin assembly protein; phosphatidylinositol-binding clathrin assembly protein; PICALM; rCALM
Gene Symbols Picalm
Host Species Rabbit
Immunogen A synthesized peptide derived from human PICALM(Accession Q13492), corresponding to amino acid residues M617-M652.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 233489, 8301, 89816
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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