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Thermo Scientific Chemicals Calmidazolium Chloride

Catalog No. AAJ63270MA
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Quantity:
10 mg

Description

CAS: 57265-65-3 | C31H23Cl7N2O, C31H24Cl7N2O | 688.70 g/mol

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+ transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+ influx distinct from store-operated Ca2+ entry and unaccompanied by Ca2+ store depletion, mobilizing stores and evoking a Ca2+ signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 57265-65-3
Molecular Formula C31H23Cl7N2O, C31H24Cl7N2O
Molecular Weight (g/mol) 688.70
InChI Key LBFGPQFQXRJXDI-UHFFFAOYNA-N
IUPAC Name 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-2,3-dihydro-1H-imidazole hydrochloridyl
SMILES [Cl].ClC1=CC=C(C=C1)C(N1CN(CC(OCC2=CC=C(Cl)C=C2Cl)C2=CC=C(Cl)C=C2Cl)C=C1)C1=CC=C(Cl)C=C1

Specifications

Quantity 10 mg
Description White
For Use With (Application) Inhibits the calcium-calmodulin dependent phosphodiesterase
Formula Weight 687.71
Form Solid

Safety and Handling

Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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