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Invitrogen™ Calpain 3 Polyclonal Antibody
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Catalog No. PIPA5103692
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PIPA5103692 100 μL
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Catalog No. PIPA5103692 Supplier Invitrogen™ Supplier No. PA5103692
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CAPN3.

Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calpain 3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Capn3
Gene Accession No. P16259, P20807, Q64691
Gene Alias AI323605; calcium-activated neutral proteinase 3; calpain 3; calpain 3, (p94); calpain L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; calpain-3; CANP 3; CANP3; CANPL3; Capa3; Capa-3; CAPN 3; CAPN3; LGMD 2A; LGMD2; LGMD2A; Lp82; Lp84; Lp85; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; NCL1; nCL-1; New calpain 1; p94; skeletal muscle specific calpain p94
Gene Symbols Capn3
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAPN3(Accession P20807), corresponding to amino acid residues E257-R307.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12335, 29155, 825
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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