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Invitrogen™ Calpain 6 Polyclonal Antibody
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Catalog No. PIPA5103693
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PIPA5103693 100 μL
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Catalog No. PIPA5103693 Supplier Invitrogen™ Supplier No. PA5103693
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CAPN6.

Calpain-6, also known as calpamodulin or calpain-X, is an intracellular, calcium-dependent cysteine protease. Calpain-6 has a much more tissue-specific expression in adults than the ubiquitous calpain-1 and calpain-2, and has thus far been found primarily in the placenta, although it is expressed embryonically in a number of tissues. The classical calpain family members consist of a common small subunit (calpain-4), and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain T in calpains 5 and 6). Located on the X chromosome, the calpain-6 sequence lacks the EF hand calcium-binding motif found in domain-IV of the classical calpains. In addition, the canonical active site Cys, His and Asn are modified to Lys, His, Asn in human and Lys, Tyr, Asn in mouse calpain-6, making it unlikely that calpain-6 is proteolytically active.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calpain 6
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CAPN6
Gene Accession No. O35646, Q9Y6Q1
Gene Alias calpain 6; calpain-6; Calpain-like protease X-linked; calpamodulin; CalpM; CANPX; Capa6; CAPN6; CAPNX; DJ914P14.1
Gene Symbols CAPN6
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAPN6(Accession Q9Y6Q1), corresponding to amino acid residues P346-H396.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12338, 827
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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