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Invitrogen™ Calpain 7 Polyclonal Antibody
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Catalog No. PA550205
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100 μL
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PA550205 100 μL
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Catalog No. PA550205 Supplier Invitrogen™ Supplier No. PA550205
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total CAPN7 protein.

Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calpain 7
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CAPN7
Gene Accession No. Q9R1S8, Q9Y6W3
Gene Alias AU022319; calpain 7; calpain like protease; CALPAIN7; calpain-7; Capn7; homolog of Aspergillus Nidulans PALB; palB homolog; PALBH
Gene Symbols CAPN7
Host Species Rabbit
Immunogen Fusion protein corresponding to residues near the C terminal of human calpain 7.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12339, 23473
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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