Invitrogen™ Calpain 7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561260

Catalog No. PIPA561260

Description

Immunogen sequence: AVFYYKEAAQ ALIYAEMAGS SLENIQEKIT EYLERVQALH SAVQSKSADP LKSKHQLDLE RAHFLVTQAF DEDEKENVED AIELYTEAVD LCLKTSYETA DKVLQNK Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.

Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.

Specifications

• Antigen: Calpain 7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAPN7
• Gene Alias: AU022319; calpain 7; calpain like protease; CALPAIN7; calpain-7; Capn7; homolog of Aspergillus Nidulans PALB; palB homolog; PALBH
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23473
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6W3
• Gene Symbols: CAPN7
• Immunogen: Recombinant protein corresponding to Human Calpain 7. Recombinant protein control fragment (Product #RP-88629).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG