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Invitrogen™ Calpastatin Monoclonal Antibody (2G11D6)
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Catalog No. MA3945
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100 μL
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Catalog No. Quantity
MA3945 100 μL
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Catalog No. MA3945 Supplier Invitrogen™ Supplier No. MA3945
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Description

Mouse Monoclonal Antibody

MA3-945 detects calpastatin from bovine, human, canine, pig, rabbit, and rat tissues and cells. This antibody does not cross-react with calpains or calmodulin. MA3-945 has been successfully used in Western blot, immunohistochemistry, and immunocytochemical procedures. By Western blot, this antibody detects 150, 125, 90 and 70 kDa proteins which have been suggested to be proteins translated from different start sites of the calpastatin gene. Immunofluorescence staining of calpastatin in porcine LLC-PK1 cells with MA3-945 results in diffuse cytoplasmic staining and weak nuclear staining. The MA3-945 antigen is bovine skeletal muscle calpastatin. This antibody recognizes an epitope found between amino acid residues 295-501 (domain II) of human calpastatin.

Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calpastatin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2G11D6
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites, PBS with 0.05% sodium azide
Gene Cast
Gene Accession No. P08855, P12675, P20810, P20811, P27321
Gene Alias BS-17; Calpain inhibitor; calpastatin; calpastatin isoform III; calpastatin precursor (EC 3.4.22.17); calpastatin type 1; calpastatin type 2; calpastatin type 3; calpastatin type I; calpastatin type II; calpastatin type III; calpastatin type IV; Cast; Erythrocyte calpastatin; heart calpastatin; PLACK; Sperm BS-17 component; type III calpastatin
Gene Symbols Cast
Host Species Mouse
Immunogen Bovine skeletal muscle calpastatin.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009098, 25403, 281039, 397135, 479148, 831
Target Species Bovine, Canine, Human, Pig, Rabbit, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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