Calponin 1 Monoclonal Antibody (EP798Y), Invitrogen™

Rabbit Monoclonal Antibody

Supplier:  Thermo Scientific MA514464

Catalog No. PIMA514464

Description

MA5-14464 targets Calponin-1 in IHC (P) applications and shows reactivity with Human samples. The MA5-14464 immunogen is a synthetic peptide derived from near the C-terminus of human Calponin-1.

Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.

Specifications

• Antigen: Calponin 1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: tissue culture supernatant with 0.09% sodium azide
• Gene Accession No.: P51911
• Gene Symbols: CNN1
• Immunogen: A synthetic peptide derived from near the C-terminus of human Calponin-1
• Regulatory Status: RUO
• Gene ID (Entrez): 1264
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Clone: EP798Y
• Conjugate: Unconjugated
• Gene: CNN1
• Gene Alias: Basic calponin; calponin; calponin 1; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; calponin H1, smooth muscle; Calponin-1; calponins, basic; CN; CNN1; CnnI; epididymis secretory protein Li 14; h1-calponin; HEL-S-14; similar to calponin 1, basic, smooth muscle; Sm-Calp; SMCC; smooth muscle calponin h1
• Host Species: Rabbit
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG